What can Spheroids do for you? Exploring the fine balance between throughput and physiological relevance


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“Context of Use”. A little-known phrase but one that has profound implications. This phrase underscores the importance of considering the practical and real-world aspects of how something will be used or applied. This understanding helps guide decision-making, assessment, and optimization to ensure that products and processes are safe, effective, and fit for their intended purpose. Understanding the context of use has profound implications across the drug discovery continuum that focusses on developing the right in vitro model to answer a specific biological question while maintaining the desired balance between physiological relevance and throughput. The InSphero 3D Insight (TM) platform delivers robust, reproducible, scalable and actionable data across different disease pathologies to provide solutions for specific contexts of use.

Madhu Nag

Chief Scientific Officer

InSphero AG

Madhu Lal-Nag earned her Doctor of Philosophy (PhD) in Molecular and Cellular Oncology from The George Washington University and her Master’s in Bioscience Business from The Keck Graduate Institute of Applied Biosciences, Claremont, CA. Her main passion lies in being able to bridge the gap between the academic and the translational aspects of cutting-edge science in oncology, metabolic diseases and investigative toxicology, and in using the results of current therapeutic regimens to creatively translate cutting edge research to immediately serve patient need. Her research interests lie in the development of predictive alternative models for safety and efficacy in drug development and evaluation. This is evidenced by her work at the National Center for Advancing Translational Sciences (NCATS/NIH) as the Director of the Trans NIH RNAi Facility as well as at the USFDA as Program Director where she focused on the development of single and multi-cellular tumor spheroids for high throughput small molecule and functional genomics screening and the characterization and validation of these systems for regulatory adoption. She currently serves as the Chief Scientific Officer at InSphero where she joins incredibly an talented team that continues to innovate the drug discovery process by leveraging the best of biology and technology to develop more predictive and precise in vitro models.

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What can Spheroids do for you? Exploring the fine balance between throughput and physiological relevance
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Open to view video. “Context of Use”. A little-known phrase but one that has profound implications. This phrase underscores the importance of considering the practical and real-world aspects of how something will be used or applied. This understanding helps guide decision-making, assessment, and optimization to ensure that products and processes are safe, effective, and fit for their intended purpose. Understanding the context of use has profound implications across the drug discovery continuum that focusses on developing the right in vitro model to answer a specific biological question while maintaining the desired balance between physiological relevance and throughput. The InSphero 3D Insight (TM) platform delivers robust, reproducible, scalable and actionable data across different disease pathologies to provide solutions for specific contexts of use.
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