Biologics as Drug Therapy

Recorded On: 09/22/2021

This course is a brief introduction to and summary of the topic of biologics as drug therapy. It centers on the things that biologics can do (that small drug molecules also do) but more importantly what some biologics can do that small molecule drugs cannot do. In addition, safety issues with biologics can be different from those of small molecules and most certainly the pharmacokinetics of biologics is a unique challenge as compared to small molecules. The specific topics covered in this course include recombinant replacement protein biologics (assessment of biological activity, production, quality control, heterogeneity, removal of undruggable proteins through PROTACs), peptides (measurement of response, biased peptide signaling, methods to demonstrate target engagement), immunotherapy (vaccines, antibody approaches to modifying the immune system), antibodies (features, agonism, antagonism, antibody-drug complexes, antibody scavenging of endogenous species), and Nucleotide-based therapies (DNA- Gene therapy, CRISPR, RNA; exploiting the siRNA system). In addition, development issues with biologics will be addressed such as specific safety topics (immunogenicity) and importantly pharmacokinetics. Specifically, the delivery of biologics can be challenging and distribution and duration also a concern. Finally, mention of determining in vivo effectiveness will be discussed.

Terrence Kenakin, Ph.D.

Professor of Pharmacology

UNC School of Medicine, Chapel Hill, NC

Terry Kenakin got his BSc in chemistry and PhD in Pharmacology at the University of Alberta, Edmonton, Canada. After a post-doctoral Fellowship in University College, London, he joined Burroughs-Wellcome in Research Triangle Park NC where he spent 7 years in drug discovery. He then moved to GlaxoSmithKline for 25 years and then to the University of North Carolina School of Medicine where he has been a Professor of Pharmacology for 6 years. He has written 10 books on Pharmacology, is the Editor in Chief of the Journal of Receptors and Signal Transduction, is on numerous Editorial Boards and has written many reviews and original papers on receptor pharmacology.


Biologics as Drug Therapy - Part 1
Open to view video.
Open to view video.
Biologics as Drug Therapy - Part 2
Open to view video.
Open to view video.